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Claramines: A New Class Of Broad‐Spectrum Antimicrobial Agents With Bimodal Activity
ChemMedChem ( IF 3.4 ) Pub Date : 2018-04-10 , DOI: 10.1002/cmdc.201800073
Marine Blanchet 1 , Diane Borselli 2 , Anne Rodallec 1 , Franck Peiretti 3 , Nicolas Vidal 4 , Jean-Michel Bolla 2 , Carole Digiorgio 5 , Kelly R. Morrison 6 , William M. Wuest 6 , Jean Michel Brunel 1
Affiliation  

The emergence of multidrug‐resistant bacteria and pathogens has created an urgent need for the development of new antibiotics. Herein we report our investigations into the broad‐spectrum activity of an easily prepared water‐soluble polyaminosterol compound, namely claramine A1, against both drug‐sensitive and drug‐resistant Gram‐negative and Gram‐positive bacterial strains. We also report its peculiar mechanism of action, which differs from that of all the other well‐known classes of antibiotics, toward Gram‐negative and Gram‐positive bacteria. Given their low cytotoxicity, this class of compounds based on claramine A1 could constitute an effective response to combat the emergence of multidrug‐resistant bacteria and nosocomial diseases.

中文翻译:

Claramines:具有双峰活性的新型广谱抗菌剂

具有多重耐药性的细菌和病原体的出现迫切需要开发新的抗生素。本文中,我们报告了对一种易于制备的水溶性聚氨基固醇化合物(即克拉明胺A1)对药物敏感性和耐药性革兰氏阴性和革兰氏阳性细菌菌株的广谱活性的研究。我们还报告了其针对革兰氏阴性菌和革兰氏阳性菌的独特作用机制,该作用机制与所有其他其他著名的抗生素类别不同。由于它们的细胞毒性较低,因此这类基于claramine A1的化合物可构成有效的抗药性,以抵抗多药耐药细菌和医院内疾病的出现。
更新日期:2018-04-10
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