Abstract

Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed S_NAr reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.

Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed S_NAr reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.

中文翻译：

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通过铁催化的电子富集吡啶的SNAr反应制得磺化吡啶的简便且廉价的途径

摘要

磺酰化吡啶通过铁催化的S _N Ar反应以中等至优异的产率合成，并以广泛范围的取代吡啶和亚磺酸盐为起始原料。这种新方法显示出合成这些有用底物的优点，例如使用易于获得的廉价催化剂，防止亚磺酸盐歧化，更重要的是，提供了接触富电子吡啶底物的途径。

磺酰化吡啶通过铁催化的S _N Ar反应以中等至优异的产率合成，并以广泛范围的取代吡啶和亚磺酸盐为起始原料。这种新方法显示出合成这些有用底物的优点，例如使用易于获得的廉价催化剂，防止亚磺酸盐歧化，更重要的是，提供了接触富电子吡啶底物的途径。