The incorporation of one anti‐favoring 2′‐fluoro‐modified guanosine into the central tetrad of a (3+1)‐hybrid‐type G‐quadruplex leads to a remarkable inversion of a single G‐tract associated with a transition from a propeller loop into a lateral loop. These topological rearrangements are in line with a kinetic partitioning mechanism for quadruplex folding.

中文翻译：

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氟介导的G四联体折叠途径的编辑

在 （3 + 1）杂交型G四联体的中心四联体中加入一种抗偏性2'-氟修饰的鸟苷会导致与螺旋桨过渡相关的单个G显着倒转循环成横向循环。这些拓扑重排符合用于四重折叠的动力学分配机制。