The combination of oligonucleotides and synthetic supramolecular systems allows for novel and long‐needed modes of regulation of the self‐assembly of both molecular elements. Discotic molecules were conjugated with short oligonucleotides and their assembly into responsive supramolecular wires studied. The self‐assembly of the discotic molecules provides additional stability for DNA‐duplex formation owing to a cooperative effect. The appended oligonucleotides allow for positional control of the discotic elements within the supramolecular wire. The programmed assembly of these hybrid architectures can be modulated through the DNA, for example, by changing the number of base pairs or salt concentration, and through the discotic platform by the addition of discotic elements without oligonucleotide handles. These hybrid supramolecular‐DNA structures allow for advanced levels of control over 1D dynamic platforms with responsive regulatory elements at the interface with biological systems.

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杂多寡核苷酸/超分子分子线的双输入调节和位置控制

寡核苷酸和合成的超分子系统的组合为两种分子元素的自组装提供了新的和长期需要的调节方式。将盘状分子与短寡核苷酸缀合，并将其组装成响应性超分子丝。由于协同效应，盘状分子的自组装为DNA双链体的形成提供了额外的稳定性。所附的寡核苷酸允许对超分子丝内的盘状元件进行位置控制。这些杂合体系结构的程序化装配可通过DNA进行调节，例如，通过改变碱基对的数量或盐浓度，以及通过添加无寡核苷酸手柄的盘状元件通过盘状平台进行调节。