Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

中文翻译：

---

用 CDK8 抑制剂瞄准糖酵解

有氧条件下对糖酵解的依赖，癌细胞中常见的代谢紊乱，表明了治疗机会。现在，通过化学遗传学，CDK8（一种与 Mediator 转录共激活因子复合物相关的激酶）已成为糖酵解的上游诱导剂和抗癌药物发现的可能靶点。