Metabolic surgical procedures, such as Roux-en-Y gastric bypass (RYGB), uniquely reprogram feeding behavior and body weight in obese subjects. Clinical neuroimaging and animal studies are only now beginning to shed light on some of the underlying central mechanisms. We present here the roles of key brain neurotransmitter/neuromodulator systems in food choice, value, and intake at various stages after RYGB. In doing so, we elaborate on how known signals emanating from the reorganized gut, including peptide hormones and microbiota products, impinge on newly mapped homeostatic and hedonic brain feeding circuits. Continued progress in the rapidly evolving field of metabolic surgery will inform the design of more effective weight-loss compounds.

中文翻译：

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Roux-en-Y胃绕道术后的脑供血回路

代谢外科手术，例如 Roux-en-Y 胃绕道术 (RYGB)，独特地重新编程肥胖受试者的进食行为和体重。临床神经影像学和动物研究现在才开始阐明一些潜在的中枢机制。我们在此介绍了 RYGB 后各个阶段的关键脑神经递质/神经调节系统在食物选择、价值和摄入方面的作用。在此过程中，我们详细说明了从重组肠道发出的已知信号（包括肽激素和微生物群产物）如何影响新映射的稳态和享乐大脑喂养回路。代谢外科快速发展领域的持续进步将为设计更有效的减肥化合物提供信息。