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Laser-based spectrometer for optical trace gas detection in young adults with autism
Microchemical Journal ( IF 4.8 ) Pub Date : 2018-05-01 , DOI: 10.1016/j.microc.2018.01.014 Ana M. Bratu , Mioara Petrus , Cristina Popa
Microchemical Journal ( IF 4.8 ) Pub Date : 2018-05-01 , DOI: 10.1016/j.microc.2018.01.014 Ana M. Bratu , Mioara Petrus , Cristina Popa
Abstract Autism is known as a complex neurodevelopmental disability that involve a combination of impairments in communication, reciprocal social interaction, and stereotypic behaviors. Many studies linked oxidative stress (OS) with the etiopathogenesis of Autism Spectrum Disorders (ASD), but the literature reports somewhat contradictory results. The aim of our study was to evaluate ethylene as a by-products of OS in human body, in people with autism. We used a laser-based spectrometer for optical trace ethylene detection. The results indicated that OS was not significantly increased in this disorder. As a by-product of OS exhaled ethylene from adults with autism presented very small concentration differences compared to healthy controls. The possible responsible factor for the normality between the concentrations of breath ethylene at young adults with autism and control adults could be explained by the antioxidants intake together with the lifestyle and dietary patterns. Additional studies are needed to determine carefully which antioxidant will have the greatest therapeutic benefit considering the importance of oxidative stress in many biological reactions.
中文翻译:
用于自闭症青年人光学痕量气体检测的激光光谱仪
摘要 自闭症被认为是一种复杂的神经发育障碍,它涉及沟通、互惠社会互动和刻板行为方面的障碍。许多研究将氧化应激 (OS) 与自闭症谱系障碍 (ASD) 的发病机制联系起来,但文献报道的结果有些矛盾。我们研究的目的是评估乙烯作为自闭症患者体内 OS 的副产品。我们使用基于激光的光谱仪进行光学痕量乙烯检测。结果表明,这种疾病的 OS 没有显着增加。作为 OS 的副产品,与健康对照相比,自闭症成人呼出的乙烯浓度差异非常小。自闭症青年和对照组成年人呼吸乙烯浓度正常的可能原因可以通过抗氧化剂摄入量以及生活方式和饮食模式来解释。考虑到氧化应激在许多生物反应中的重要性,需要进行额外的研究来仔细确定哪种抗氧化剂具有最大的治疗益处。
更新日期:2018-05-01
中文翻译:
用于自闭症青年人光学痕量气体检测的激光光谱仪
摘要 自闭症被认为是一种复杂的神经发育障碍,它涉及沟通、互惠社会互动和刻板行为方面的障碍。许多研究将氧化应激 (OS) 与自闭症谱系障碍 (ASD) 的发病机制联系起来,但文献报道的结果有些矛盾。我们研究的目的是评估乙烯作为自闭症患者体内 OS 的副产品。我们使用基于激光的光谱仪进行光学痕量乙烯检测。结果表明,这种疾病的 OS 没有显着增加。作为 OS 的副产品,与健康对照相比,自闭症成人呼出的乙烯浓度差异非常小。自闭症青年和对照组成年人呼吸乙烯浓度正常的可能原因可以通过抗氧化剂摄入量以及生活方式和饮食模式来解释。考虑到氧化应激在许多生物反应中的重要性,需要进行额外的研究来仔细确定哪种抗氧化剂具有最大的治疗益处。