Abstract The optimization of phenolic compounds extraction from extra virgin olive oil (EVOO) was achieved applying a Response Surface Methodology. A simple and straightforward method for the extraction of phenolic compounds from EVOO has been optimized in the presence of functionalized gold nanoparticles (AuNPs). AuNPs were prepared in the presence of Cysteamine as stabilizing thiol (AuNPs-Cys) in order to obtain a water stable colloidal suspension. The obtained AuNPs-Cys, with mean size of about 10 nm were observed by AFM and used as extracting phase of phenolic compounds from EVOO. External parameters influencing the extraction were studied and a Central Composite Design (CCD) was applied for the optimization. The role of AuNPs-Cys quantity (4–12 mg), mixing and contact time (30–120 min), interfering (olive oil quantity) and phenolic compounds concentration (50–500 ppm) were analyzed. An equation model was obtained by applying CCD, with a high significativity (p

中文翻译：

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响应面法优化用功能化金纳米粒子从特级初榨橄榄油中提取酚类化合物

摘要 应用响应面方法优化了从特级初榨橄榄油 (EVOO) 中提取酚类化合物。在功能化金纳米粒子 (AuNPs) 的存在下，优化了一种从 EVOO 中提取酚类化合物的简单直接的方法。AuNPs 在半胱胺作为稳定硫醇 (AuNPs-Cys) 的存在下制备，以获得水稳定的胶体悬浮液。获得的AuNPs-Cys，平均尺寸约为10 nm，通过AFM观察，并用作EVOO酚类化合物的提取相。研究了影响提取的外部参数，并应用了中央复合设计 (CCD) 进行优化。AuNPs-Cys 数量（4-12 毫克）、混合和接触时间（30-120 分钟）的作用，分析了干扰物（橄榄油量）和酚类化合物浓度（50-500 ppm）。应用CCD得到方程模型，显着性高（p