Influenza vaccination aims to prevent infection by influenza virus and reduce associated morbidity and mortality; however, vaccine effectiveness (VE) can be modest, especially for subtype A(H3N2). Low VE has been attributed to mismatches between the vaccine and circulating influenza strains and to the vaccine’s elicitation of protective immunity in only a subset of the population. The low H3N2 VE in the 2012–2013 season was attributed to egg-adaptive mutations that created antigenic mismatch between the actual vaccine strain (IVR-165) and both the intended vaccine strain (A/Victoria/361/2011) and the predominant circulating strains (clades 3C.2 and 3C.3).

中文翻译：

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免疫原性差，而不是疫苗株适应性强，可能说明2012-2013年H3N2流感疫苗的有效性低

流感疫苗接种旨在防止流感病毒感染并降低相关的发病率和死亡率；但是，疫苗效力（VE）可能不高，尤其是对于亚型A（H3N2）。低VE被归因于疫苗和流行的流感病毒株之间的不匹配，以及疫苗仅在一部分人群中引起保护性免疫。2012-2013季H3N2 VE较低是由于卵适应性突变导致实际疫苗株（IVR-165）与预期疫苗株（A / Victoria / 361/2011）和主要循环株之间的抗原错配应变（包层3C.2和3C.3）。