Immune Infiltration in Invasive Lobular Breast Cancer,Journal of the National Cancer Institute

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Immune Infiltration in Invasive Lobular Breast Cancer
Journal of the National Cancer Institute ( IF 10.3 ) Pub Date : 2018-02-20 , DOI: 10.1093/jnci/djx268
Christine Desmedt ₁ , Roberto Salgado _{1,

2} , Marco Fornili ₃ , Giancarlo Pruneri _{4,

5} , Gert Van den Eynden ₆ , Gabriele Zoppoli ₇ , Françoise Rothé ₁ , Laurence Buisseret ₁ , Soizic Garaud ₆ , Karen Willard-Gallo ₆ , David Brown ₁ , Yacine Bareche ₁ , Ghizlane Rouas ₁ , Christine Galant ₈ , François Bertucci ₉ , Sherene Loi ₁₀ , Giuseppe Viale ₅ , Angelo Di Leo ₁₁ , Andrew R Green ₁₂ , Ian O Ellis _{12,

13} , Emad A Rakha _{12,

13} , Denis Larsimont ₁₄ , Elia Biganzoli ₃ , Christos Sotiriou ₁

Affiliation

J.C. Heuson Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium
Department of Pathology, GZA Ziekenhuizen, Campus Sint Augustinus, Wilrijk, Belgium
Unit of Medical Statistics, Biometry and Bioinformatics “Giulio A. Maccacaro,” Department of Clinical Sciences and Community Health, University of Milan Campus, Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Division of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Department of Pathology, European Institute of Oncology, University of Milan, Milan, Italy
Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
Department of Internal Medicine (DiMI), University of Genoa and IRCCS San Martino-National Cancer Institute, Genoa, Italy
Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium
Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France
Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Instituto Toscano Tumori, Prato, Italy
Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK
Histopathology, Nottingham University Hospitals NHS Trust, Nottingham, UK
Department of Pathology, Université Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium

Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels, and composition of tumor-infiltrating lymphocytes (TILs) and their association with clinico-pathological and outcome variables in ILC, and to compare them with IDC.

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