In this research, the high conductivity of nickel chloride solution as well as the ability of nickel ions in establishing particular bonds with curcumin was benefited to fabricate a new electrochemical sensor based on nickel chloride solution modified glassy carbon electrode (NiCl₂/GCE) for detection and measurement of curcumin in human blood serum. Atomic force microscope (AFM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) methods indicated that using nickel chloride solution for the modification of the glassy carbon electrode (GCE) surface had a significant effect on improvement of the electrode performance. Differential pulse voltammetry (DPV) was used for quantitative measurement of curcumin, which exhibited the linear response of NiCl₂/GCE toward curcumin within the concentration range of 10–600 μM and provided the detection limit of 0.109 μM for curcumin in human blood serum.

中文翻译：

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基于氯化镍溶液修饰玻碳电极的新型灵敏电化学传感器测定姜黄素

在这项研究中，氯化镍溶液的高电导率以及镍离子与姜黄素建立特定键的能力，有利于制造一种基于氯化镍溶液修饰的玻碳电极（NiCl ₂ / GCE）的新型电化学传感器血清中姜黄素的测定和测定。原子力显微镜（AFM），循环伏安法（CV）和电化学阻抗谱（EIS）方法表明，使用氯化镍溶液修饰玻碳电极（GCE）表面对改善电极性能具有显着影响。差示脉冲伏安法（DPV）用于姜黄素的定量测定，其表现出NiCl ₂的线性响应/ GCE对姜黄素的浓度范围为10–600μM，对人血清中的姜黄素的检出限为0.109μM。