Autotaxin is a dual-function ecto-enzyme, encoded by the gene ENPP2, which is the primary source of the bioactive signaling lipid, lysophosphatidic acid. Aberrations in autotaxin/lysophosphatidic acid signaling have been associated with a number of neurological, psychiatric, neoplastic, and neurodevelopmental conditions, such as pain, pruritus, glioblastoma multiforme, multiple sclerosis, Alzheimer’s disease, hydrocephalus, and schizophrenia. This Viewpoint offers a brief overview of the likely indications for therapeutic targeting of autotaxin, in disorders affecting the nervous system.

中文翻译：

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紫杉醇抑制剂（一种生物活性脂质产生的溶血磷脂酶D）在影响神经系统疾病中的潜在治疗应用

Autotaxin是一种双重功能的外切酶，由基因ENPP2编码，该基因是生物活性信号脂质溶血磷脂酸的主要来源。自分泌运动蛋白/溶血磷脂酸信号的异常与许多神经系统疾病，精神病学，赘生物和神经发育疾病有关，例如疼痛，瘙痒，多形性胶质母细胞瘤，多发性硬化，阿尔茨海默氏病，脑积水和精神分裂症。该观点简要概述了在影响神经系统的疾病中靶向治疗自分泌运动素的可能适应症。