New polymers are needed to address the shortcomings of commercially available materials for soft tissue repair. Herein, we investigated a series of l-valine-based poly(ester urea)s (PEUs) that vary in monomer composition and the extent of branching as candidate materials for soft tissue repair. The preimplantation Young’s moduli (105 ± 30 to 269 ± 12 MPa) for all the PEUs are comparable to those of polypropylene (165 ± 5 MPa) materials currently employed in hernia-mesh repair. The 2% branched poly(1-VAL-8) maintained the highest Young’s modulus following 3 months of in vivo implantation (78 ± 34 MPa) when compared to other PEU analogues (20 ± 6–45 ± 5 MPa). Neither the linear or branched PEUs elicited a significant inflammatory response in vivo as noted by less fibrous capsule formation after 3 months of implantation (80 ± 38 to 103 ± 33 μm) relative to polypropylene controls (126 ± 34 μm). Mechanical degradation in vivo over three months, coupled with limited inflammatory response, suggests that l-valine-based PEUs are translationally relevant materials for soft tissue applications.

中文翻译：

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线性和支链基于缬氨酸的聚（酯脲）在软组织应用中的临床前和体内评估

需要新的聚合物以解决用于软组织修复的市售材料的缺点。在此，我们研究了一系列的升-基于缬氨酸的聚（酯脲）（PEU），其单体组成和分支程度有所不同，可作为软组织修复的候选材料。所有PEU的植入前杨氏模量（105±30至269±12 MPa）与目前用于疝气网修补的聚丙烯（165±5 MPa）材料相当。与其他PEU类似物（20±6–45±5 MPa）相比，在体内植入3个月后（78±34 MPa），2％支化的poly（1-VAL-8）保持了最高的杨氏模量。相对于聚丙烯对照（126±34μm），植入3个月后（80±38至103±33μm）纤维状胶囊形成较少，线性或分支PEU均未引起明显的体内炎症反应。超过三个月的体内机械降解，加上有限的炎症反应，升缬氨酸基于PEUs翻译是软组织应用的相关材料。