In this paper, we propose a new shape memory polymer (SMP) composite with excellent near-infrared (NIR)-photoresponsive shape memory performance and biodegradability. The composite is fabricated by using piperazine-based polyurethane (PU) as thermo-responsive SMP incorporated with black-phosphorus (BP) sheets as NIR photothermal nanofillers. Under 808 nm light irradiation, the incorporated BP sheets with concentration of only 0.08 wt% enable rapid temperature increase over the glass temperature of PU and trigger the shape change of the composite with shape recovery rate of ∼100%. The in vitro and in vivo toxicity examinations demonstrate the good biocompatibility of the PU/BP composite, and it degrades naturally into non-toxic carbon dioxide and water from PU and non-toxic phosphate from BP. By implanting PU/BP columns into back subcutis and vagina of mice, they exhibit excellent shape memory activity to change their shape quickly under moderate 808 nm light irradiaiton. Such SMP composite enable the development of intelligent implantable devices, which can be easily controlled by the remote NIR light and degrade gradually after performing the designed functions in the body.

在本文中，我们提出了一种新型的形状记忆聚合物（SMP）复合材料，该复合材料具有出色的近红外（NIR）-光响应形状记忆性能和可生物降解性。该复合材料是通过使用哌嗪基聚氨酯（PU）作为热敏SMP并结合黑磷（BP）片材作为NIR光热纳米填料而制成的。在808 nm的光照射下，掺入的BP片材的浓度仅为0.08 wt％，可使温度在PU的玻璃温度范围内迅速升高，并引发复合材料的形状变化，其形状恢复率约为100％。在体外和体内毒性检查表明，PU / BP复合材料具有良好的生物相容性，并且可以自然降解为PU产生的无毒二氧化碳和水，以及BP产生的无毒磷酸盐。通过将PU / BP色谱柱植入小鼠的皮下组织和阴道，它们具有出色的形状记忆活性，可以在中等808 nm光照射下迅速改变其形状。这种SMP复合材料使智能植入设备的开发成为可能，该设备可通过远程NIR光线轻松控制，并在体内执行设计的功能后逐渐退化。