Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for “integrated selection of allele favored by evolution”), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations.

中文翻译：

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在积极的选择性扫描中鉴定出偏爱的突变

在种群基因组学数据中捕获选择性扫描特征的大多数方法都无法识别出选择偏爱的特定突变。我们提出了iSAFE（用于“进化优先选择的等位基因的综合选择”），该方法使研究人员能够通过使用仅来自种群遗传学信号的统计数据，在大区域（约5 Mbp）内准确查明有利的突变。iSAFE不需要了解人口统计学，所选择的表型或突变的功能注释。