The progress of the chemistry of carbon nanotubes (CNT) and graphene derivatives [mainly graphene oxide (GO)] has produced a number of technologically advanced drug delivery systems (DDS) that have been used in the field of nanomedicine, mostly in studies related to oncology. However, such a demanding field of research requires continuous improvements in terms of efficiency, selectivity and versatility. The loading of two, or more, bioactive components on the same nanoparticle offers new possibilities for treating cancer, efficiently addressing issues related both to biodistribution and pharmacokinetics. Nanostructured carbon materials (NCM), with their high surface area, their efficient cellular membrane crossing and their chemical versatility are ideal candidates for easy hetero-decoration and exploitation as advanced DDS. This review describes the achievements obtained in this area focusing on those studies in which two or more active components were loaded onto the DDS.

中文翻译：

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纳米结构碳材料的组合疗法：底部仍有空间

碳纳米管（CNT）和石墨烯衍生物[主要是氧化石墨烯（GO）]的化学进步已经产生了许多技术先进的药物递送系统（DDS），这些系统已用于纳米医学领域，主要用于与肿瘤学。但是，这种苛刻的研究领域要求在效率，选择性和多功能性方面进行持续改进。在同一纳米粒子上加载两种或多种生物活性成分，为治疗癌症提供了新的可能性，可有效解决与生物分布和药代动力学相关的问题。纳米结构的碳材料（NCM）具有高的表面积，有效的细胞膜穿透能力和化学多功能性，是易于异质修饰和用作高级DDS的理想候选材料。