A phytochemical study on the roots of Pongamia pinnata (L.) Pierre yielded 52 flavonoids, including four previously undescribed flavone and four previously undescribed chalcone derivatives. The structures of the isolated compounds were determined on the basis of the 1D, 2D NMR, and mass spectroscopic data. The absolute configurations of the compounds were assigned via the specific rotation, Mosher's method, as well as the electronic circular dichroism (ECD) spectra. All the isolates were evaluated for their inhibitory effects on NO production in LPS-stimulated BV-2 microglial cells. Ten compounds showed significant inhibitory effects against NO production, comparable to the positive control, dexamethasone.

中文翻译：

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来自 Pongamia pinnata (L.) Pierre 根的抗炎黄酮和查耳酮衍生物

对 Pongamia pinnata (L.) Pierre 根的植物化学研究产生了 52 种黄酮类化合物，包括四种以前未描述过的黄酮和四种以前未描述过的查耳酮衍生物。根据一维、二维核磁共振和质谱数据确定了分离化合物的结构。通过比旋光度、Mosher 方法以及电子圆二色性 (ECD) 光谱确定化合物的绝对构型。评估了所有分离株对 LPS 刺激的 BV-2 小胶质细胞中 NO 产生的抑制作用。与阳性对照地塞米松相比，10 种化合物显示出对 NO 产生的显着抑制作用。