Several in vitro studies have proposed syringic acid as a benzoic acid derivative found in plant foods, which can reduces collagen-stimulated platelet aggregation. Nonetheless, to date, there are no reports elucidating the role of syringic acid in platelet activation and thrombosis. Syringic acid inhibited clot formation and procoagulant protease activity and induced blood clot degradation. Syringic acid decreased the expression of density-enhanced phosphatase-1 (DEP-1)/protein tyrosine phosphatase-1B (PTP1B)/α_IIbβ₃, as well as the phosphorylation of kinases in collagen/epinephrine-stimulated platelets both in vitro and in vivo. Moreover, syringic acid inhibited the secretion of granule constituents, clot retraction, and FeCl₃-induced vascular occlusion of the carotid artery. Syringic acid (up to 100 μM) did not show any effect on the viability of RAW 264.7 cells. Our findings demonstrate that syringic acid attenuate the development of thrombosis and thromboembolism by inhibiting fibrin clot formation, coagulant factors, and platelet stimulation through DEP-1/PTP1B/α_IIbβ₃/kinases.

几项体外研究提出了在植物性食品中发现丁香酸作为苯甲酸衍生物，它可以减少胶原蛋白刺激的血小板聚集。然而，迄今为止，没有报道阐明丁香酸在血小板活化和血栓形成中的作用。丁香酸抑制血凝块形成和促凝血蛋白酶活性并诱导血凝块降解。丁香酸减少的表达密度增强磷酸酶-1（DEP-1）/蛋白酪氨酸磷酸酶1B（PTP1B）/α _IIB β ₃，以及磷酸激酶在胶原/肾上腺素刺激的血小板都在体外和体内。此外，丁香酸抑制颗粒成分的分泌，凝块收缩和FeCl ₃引起的颈动脉血管闭塞。丁香酸（高达100μM）对RAW 264.7细胞的活力没有任何影响。我们的研究结果表明，丁香酸衰减血栓形成和血栓栓塞的发展通过DEP-1 / PTP1B /α抑制纤维蛋白凝块形成，凝结剂的因素，和刺激血小板_IIB β ₃ /激酶。