Thiol‐terminated poly(δ‐valerolactone) is directly synthesized via enzymatic 6‐mercapto‐1‐hexanol initiated ring‐opening polymerization in both batch and microreactor. By using Candida antartica Lipase B immobilized tubular reactor, narrowly dispersed poly(δ‐valerolactone) with higher thiol fidelity is more efficiently prepared in contrast to the batch reactor. Moreover, the integrated enzyme packed tubular reactor system is established to perform the chain extension experiments. Thiol‐terminated poly(δ‐valerolactone)‐block‐poly(ε‐caprolactone) and poly(ε‐caprolactone)‐block‐poly(δ‐valerolactone) are easily prepared by modulating the monomer introduction sequence.

中文翻译：

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巯基封端的聚（δ-戊内酯）和嵌段共聚物的酶促连续流合成

巯基封端的聚（δ-戊内酯）是通过酶催化的6-巯基-1-己醇引发的间歇反应和微反应器中的开环聚合反应直接合成的。与分批反应器相比，通过使用南极假丝酵母脂肪酶B固定式管式反应器，可以更有效地制备具有较高硫醇保真度的窄分散聚（δ-戊内酯）。此外，建立了集成的酶填充管式反应器系统以进行扩链实验。硫醇封端的聚（δ戊内酯） -嵌段-聚（ε -己内酯）和聚（ε -己内酯） -嵌段-聚（δ戊内酯）很容易通过调节单体引入序列制备。