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Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
Acta Neuropathologica ( IF 12.7 ) Pub Date : 2018-02-15 , DOI: 10.1007/s00401-018-1822-2
Zane Jaunmuktane 1, 2 , Annelies Quaegebeur 1 , Ricardo Taipa 3 , Miguel Viana-Baptista 4 , Raquel Barbosa 4 , Carolin Koriath 5 , Raf Sciot 6 , Simon Mead 5, 7, 8 , Sebastian Brandner 1, 5
Affiliation  

Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA). Aβ pathology is transmissible experimentally in animals and through medical procedures in humans, such as contaminated growth hormone or dura mater transplantation in the context of iatrogenic prion disease. Here, we present four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately three decades later, caused by severe CAA. None of these patients carried pathogenic mutations associated with early Aβ pathology development. In addition, we identified in the literature four patients with a history of neurosurgical intervention and subsequent development of CAA. These findings raise the possibility that Aβ pathology may be transmissible, as prion disease is, through neurosurgical procedures.



中文翻译:

β淀粉样蛋白脑淀粉样血管病通过神经外科传播的证据

β淀粉样蛋白(Aβ)是一种沉积在阿尔茨海默病患者脑实质和脑血管中的肽,导致脑淀粉样血管病(CAA)。Aβ 病理可在动物实验中传播,也可通过人类医疗程序传播,例如医源性朊病毒病中受污染的生长激素或硬脑膜移植。在这里,我们介绍了四名患者,他们在童年或青少年时期接受过神经外科手术,并在大约三十年后因严重的 CAA 引起脑出血。这些患者均未携带与早期 Aβ 病理发展相关的致病突变。此外,我们在文献中确定了四名具有神经外科干预史和随后发生 CAA 的患者。这些发现提出了 Aβ 病理学可能像朊病毒病一样通过神经外科手术传播的可能性。

更新日期:2018-02-15
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