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Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
Nature Reviews Neurology ( IF 38.1 ) Pub Date : 2018-02-16 , DOI: 10.1038/nrneurol.2018.9
Victor L. Villemagne , Vincent Doré , Samantha C. Burnham , Colin L. Masters , Christopher C. Rowe

Most neurodegenerative disorders are associated with aggregated protein deposits. In the case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. Aβ-PET imaging has already been approved for clinical use and is being used in clinical trials of anti-Aβ therapies both for patient recruitment and as an outcome measure. These studies have shown that Aβ accumulation is a protracted process that can extend for more than 2 decades before the onset of clinical AD. This Review describes how in vivo brain imaging of Aβ pathology has revolutionized the evaluation of patients with clinical AD by providing robust and reproducible statements of global or regional brain Aβ burden and enabling the monitoring of disease progression. The role of selective tau imaging is discussed, focusing on how longitudinal tau and Aβ imaging studies might reveal the various effects (sequential and/or parallel, independent and/or synergistic) of these proteins on progression, cognition and other disease-specific biomarkers of neurodegeneration. Finally, imaging studies are discussed in the context of elucidating the respective roles of Aβ and tau in AD and in advancing our understanding of the relationship and/or interplay between these two proteinopathies.



中文翻译:

在阿尔茨海默氏病和其他疾病中对tau和淀粉样β蛋白病变进行成像

大多数神经退行性疾病与聚集的蛋白质沉积物有关。就阿尔茨海默氏病(AD)而言,细胞外淀粉样β(Aβ)聚集和细胞内tau神经原纤维缠结是该疾病的两个神经病理学特征。Aβ-PET成像已被批准用于临床,并且正在用于抗Aβ疗法的临床试验中,既可用于招募患者,也可作为结果指标。这些研究表明,Aβ的积累是一个长期的过程,在临床AD发作之前可能会持续超过20年。这篇综述描述了Aβ病理学的体内脑成像如何通过提供可靠的和可重复的全局或区域性大脑Aβ负担的陈述并实现对疾病进展的监测,彻底改变了对临床AD患者的评估。讨论了选择性tau成像的作用,重点是纵向tau和Aβ成像研究如何揭示这些蛋白对肝癌进展,认知和其他疾病特异性生物标志物的各种影响(顺序和/或平行,独立和/或协同)。神经变性。最后,在阐明Aβ和tau在AD中各自的作用以及增进我们对这两种蛋白病之间的关系和/或相互作用的理解的背景下,讨论了影像学研究。

更新日期:2018-02-16
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