^‡ These authors contributed equally to this work

Abstract

N-Sulfonylformamidines were synthesized from N-sulfonylsulfonamides by reacting with p-toluenesulfonyl chloride (TsCl) and N,N -disubstituted formamides. In this reaction, it was expected that mixing TsCl with the N,N-disubstituted formamide would generate an iminium salt (Vilsmeier reagent). The reaction avoids the use of metal catalysts and hazardous reagents, and the desired N-sulfonylformamidines were obtained in 60% to quantitative yields.

N-Sulfonylformamidines were synthesized from N-sulfonylsulfonamides by reacting with p-toluenesulfonyl chloride (TsCl) and N,N -disubstituted formamides. In this reaction, it was expected that mixing TsCl with the N,N-disubstituted formamide would generate an iminium salt (Vilsmeier reagent). The reaction avoids the use of metal catalysts and hazardous reagents, and the desired N-sulfonylformamidines were obtained in 60% to quantitative yields.

中文翻译：

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由N-磺酰基磺酰胺合成N-磺酰基甲am的新方法

^‡这些作者对这项工作做出了同等的贡献

抽象的

Ñ -Sulfonylformamidines从合成Ñ -sulfonylsulfonamides通过与反应p甲苯磺酰氯（的TsCl）和Ñ，ñ -二取代的甲酰胺。在该反应中，预期将TsCl与N，N-二取代的甲酰胺混合将产生亚胺盐（Vilsmeier试剂）。该反应避免了使用金属催化剂和有害试剂，并且以60％至定量收率获得了所需的N-磺酰基甲am。

Ñ -Sulfonylformamidines从合成Ñ -sulfonylsulfonamides通过与反应p甲苯磺酰氯（的TsCl）和Ñ，ñ -二取代的甲酰胺。在该反应中，预期将TsCl与N，N-二取代的甲酰胺混合将产生亚胺盐（Vilsmeier试剂）。该反应避免了使用金属催化剂和有害试剂，并且以60％至定量收率获得了所需的N-磺酰基甲am。