当前位置: X-MOL 学术J. Allergy Clin. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mast cells signal their importance in health and disease
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2018-02-15 , DOI: 10.1016/j.jaci.2018.01.034
Ana Olivera , Michael A. Beaven , Dean D. Metcalfe

FcεRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid release of mediators, an adaptive immune response that might have evolved as a host defense against parasites and venoms. Yet it is apparent that mast cells are also activated through non-IgE receptors, the significance of which is just beginning to be understood. This includes the Mas-related G protein–coupled receptor X2, which might contribute to reactions to diverse antimicrobials and polybasic compounds, and the adhesion G protein–coupled receptor E2, variants of which are associated with familial vibratory urticaria and are activated by mechanical vibration. Similarly, mast cells have long been recognized as the main repository for histamine, heparin, and proteases. Recent evidence also points to new functions, modes of delivery, and mechanisms of action of mast cell proteases that add new dimensions to the roles of mast cells in human biology. In addition, exposure of mast cells to environmental cues can quantitatively and qualitatively modulate their responses and thus their effect on allergic inflammation. Illustrating this paradigm, we summarize a number of recent studies implicating the injury/tissue damage cytokine IL-33 as a modulator of allergen-induced mast cell responses. We also discuss the discovery of markers associated with transformed mast cells and new potential directions in suppressing mast cell activity.



中文翻译:

肥大细胞表明其在健康和疾病中的重要性

FcεRI是肥大细胞中的主要受体,可通过诱导介体的快速释放来介导变态反应,介体是一种适应性免疫反应,可能已演变成对寄生虫和毒液的宿主防御。显然肥大细胞也可以通过非IgE受体激活,其重要性才刚刚开始被理解。这包括与Mas相关的G蛋白偶联受体X2(可能与多种抗菌剂和多元化合物发生反应)以及与G蛋白偶联的受体E2(其变体与家族性荨麻疹有关,并通过机械振动激活) 。同样,长期以来,肥大细胞被认为是组胺,肝素和蛋白酶的主要储存库。最近的证据还指出了新的功能,交付方式,肥大细胞蛋白酶的作用机制,为肥大细胞在人类生物学中的作用增加了新的维度。另外,肥大细胞暴露于环境提示可以定量和定性地调节其反应,从而调节其对过敏性炎症的影响。为了说明这一范例,我们总结了许多最新研究,这些研究牵涉损伤/组织损伤细胞因子IL-33作为过敏原诱导的肥大细胞反应的调节剂。我们还讨论了与转化的肥大细胞相关的标志物的发现和抑制肥大细胞活性的新潜在方向。肥大细胞暴露于环境提示下可以定量和定性地调节其反应,从而改变其对过敏性炎症的影响。为了说明这一范例,我们总结了许多最新研究,这些研究牵涉损伤/组织损伤细胞因子IL-33作为过敏原诱导的肥大细胞反应的调节剂。我们还讨论了与转化的肥大细胞相关的标志物的发现和抑制肥大细胞活性的新潜在方向。肥大细胞暴露于环境提示下可以定量和定性地调节其反应,从而改变其对过敏性炎症的影响。为了说明这一范例,我们总结了许多最新研究,这些研究牵涉损伤/组织损伤细胞因子IL-33作为过敏原诱导的肥大细胞反应的调节剂。我们还讨论了与转化的肥大细胞相关的标志物的发现和抑制肥大细胞活性的新潜在方向。

更新日期:2018-02-15
down
wechat
bug