The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.

中文翻译：

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新的 ADCY3 变体在肥胖病因学中起舞

肥胖相关性状的遗传病因仍然难以捉摸。最近的研究将新型 ADCY3 变体与肥胖和糖尿病联系起来，并确定了 ADCY3 介导的神经元初级纤毛信号传导在肥胖易感性中的重要作用。这些发现提供了关于肥胖病因的新信息，并提出了潜在的抗肥胖治疗策略。