Although considerable knowledge of the biosynthetic machinery of thiopeptide antibiotics has been accumulated, the regulation of their production remains unclear. In this issue ofCell Chemical Biology,Li et al. (2018)have now characterized a key transcription factor and suggest its feedback regulation by biosynthesis intermediates and the final product.

中文翻译：

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硫肽生物合成中的主开关

尽管已积累了有关硫肽抗生素生物合成机制的相当多的知识，但对其生产的调节仍不清楚。在《细胞化学生物学》杂志上，Li等人。（2018）现在已经对关键转录因子进行了表征，并提出了其通过生物合成中间体和终产物的反馈调控作用。