COQ8 proteins are homologs of atypical protein kinases required for the biosynthesis of coenzyme Q (CoQ). In this issue ofCell Chemical Biology,Reidenbach et al. (2018)show that COQ8 has an ATPase activity, required for CoQ biosynthesis, that is strongly activated by cardiolipin and small molecule mimics of early CoQ intermediates.

中文翻译：

---

深入了解古代非典型激酶对于辅酶Q生物合成必不可少的

COQ8蛋白是生物合成辅酶Q（CoQ）所需的非典型蛋白激酶的同源物。在本期《细胞化学生物学》中，Reidenbach等人。（2018）显示，COQ8具有CoQ生物合成所需的ATPase活性，该活性被心磷脂和早期CoQ中间体的小分子模拟物强烈激活。