Podocytes cover the kidney glomerular basement membrane and present the final barrier in the renal filtration system. Podocyte loss, observed in most kidney diseases, correlates with kidney function decline. In this issue ofCell Chemical Biology,Seiber et al. (2018), using a high-throughput chemical screen, identified the compound CDG-0876, which improved podocyte survival.

中文翻译：

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肾脏疾病筛查药物：靶向足细胞

足细胞覆盖肾小球基底膜，并在肾脏过滤系统中呈现出最终的屏障。在大多数肾脏疾病中观察到足细胞丢失与肾脏功能下降相关。在本期《细胞化学生物学》中，Seiber等人。（2018）使用高通量化学筛选方法鉴定了化合物CDG-0876，该化合物可改善足细胞的存活率。