Analytical chemistry represents a central aspect of doping controls. Routine sports drug testing approaches are primarily designed to address the question whether a prohibited substance is present in a doping control sample and whether prohibited methods (for example, blood transfusion or sample manipulation) have been conducted by an athlete. As some athletes have availed themselves of the substantial breadth of research and development in the pharmaceutical arena, proactive and preventive measures are required such as the early implementation of new drug candidates and corresponding metabolites into routine doping control assays, even though these drug candidates are to date not approved for human use. Beyond this, analytical data are also cornerstones of investigations into atypical or adverse analytical findings, where the overall picture provides ample reason for follow-up studies. Such studies have been of most diverse nature, and tailored approaches have been required to probe hypotheses and scenarios reported by the involved parties concerning the plausibility and consistency of statements and (analytical) facts. In order to outline the variety of challenges that doping control laboratories are facing besides providing optimal detection capabilities and analytical comprehensiveness, selected case vignettes involving the follow-up of unconventional adverse analytical findings, urine sample manipulation, drug/food contamination issues, and unexpected biotransformation reactions are thematized.

分析化学代表了掺杂控制的主要方面。常规运动药物测试方法主要用于解决以下问题：运动员的兴奋剂控制样品中是否存在违禁物质以及运动员是否进行了违禁方法（例如输血或样品处理）。由于一些运动员充分利用了药物领域的广泛研发成果，因此需要采取积极和预防措施，例如将新药物候选物和相应的代谢物尽早用于常规的兴奋剂控制测定中，即使这些药物候选物要未批准人类使用的日期。除此之外，分析数据也是对非典型或不利分析结果进行调查的基础，总体情况为后续研究提供了充分的理由。此类研究具有最广泛的性质，因此需要采用量身定制的方法来探究相关方报告中关于陈述和（分析性）事实的合理性和一致性的假设和场景。为了概述兴奋剂控制实验室除了提供最佳的检测能力和分析全面性之外还面临的各种挑战，选定的病例渐晕症涉及非常规不良分析发现，尿液样品处理，药物/食品污染问题以及意外的生物转化的跟进反应是主题化的。并需要采用量身定制的方法来探究有关各方报告中关于陈述和（分析性）事实的合理性和一致性的假设和情形。为了概述兴奋剂控制实验室除了提供最佳的检测能力和分析全面性之外还面临的各种挑战，选定的病例渐晕症涉及非常规不良分析发现，尿液样品处理，药物/食品污染问题以及意外的生物转化的跟进反应是主题化的。并需要采用量身定制的方法来探究有关各方报告中关于陈述和（分析性）事实的合理性和一致性的假设和情形。为了概述兴奋剂控制实验室除了提供最佳的检测能力和分析全面性之外还面临的各种挑战，选定的病例渐晕症涉及非常规不良分析发现，尿液样品处理，药物/食品污染问题以及意外的生物转化的跟进反应是主题化的。