当前位置: X-MOL 学术Trends Mol. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Trends in Molecular Medicine ( IF 13.6 ) Pub Date : 2018-02-13 , DOI: 10.1016/j.molmed.2018.01.008
Amanda Kallen 1 , Alex J Polotsky 2 , Joshua Johnson 2
Affiliation  

Even with the benefit of assisted reproductive technologies (ART), many women are unable to conceive and deliver healthy offspring. One common cause of infertility is the inability to produce eggs capable of contributing to live birth. This can occur despite standard-of-care treatment to maximize the recovery of eggs from growing ovarian follicles. Dormant primordial follicles in the human ovary are a ‘reserve ’ that can be exploited clinically to overcome this problem. We discuss how controlling primordial follicle growth activation (PFGA) can produce increased numbers of high-quality eggs available for fertility treatment(s). We consider the state of the art in interventions used to control PFGA, and consider genetic and epigenetic strategies on the horizon that might improve compromised oocyte quality to increase live births.



中文翻译:

未开发的储备:控制原始卵泡生长激活

即使有辅助生殖技术 (ART) 的好处,许多女性也无法怀孕和生育健康的后代。不孕症的一个常见原因是无法产生能够促进活产的卵子。尽管进行了标准护理治疗以最大限度地从生长的卵泡中恢复卵子,但仍可能发生这种情况。人类卵巢中休眠的原始卵泡是一种“储备”,临床上可以利用它来克服这个问题。我们讨论了控制原始卵泡生长激活 (PFGA) 如何产生更多的可用于生育治疗的优质卵子。我们考虑了用于控制 PFGA 的干预措施的最新技术,并考虑了可能改善受损卵母细胞质量以增加活产的遗传和表观遗传策略。

更新日期:2018-02-13
down
wechat
bug