Abstract Emulsions containing unsaturated fatty acids (UFAs) have potential in the treatment of clinical malnutrition. However, the stability of UFAs is a major problem due to the presence of double bonds, which are susceptible to oxidation, leading to the loss of nutrition and even resulting in side effects. The factors that affect the UFAs are complex, and the protective effect of single antioxidant is not satisfactory. The goal of the study was the development of UFA-enriched oil-in-water (O/W) emulsions with improved stability, simultaneously employing a hydrophilic (catechol) and a hydrophobic (tocopherol) antioxidant, and then to investigate the stabilization mechanisms of catechol and tocopherol for emulsions. The emulsions obtained in this study showed uniform nanoscale droplets and good storage stability for three months under accelerated conditions. More than 93.0% of fatty acids remained unchanged after six months of storage, which demonstrated the protective effects of catechol and tocopherol. The dual antioxidant emulsions were remarkably effective in protecting the UFAs compared to emulsions with a single antioxidant or without any antioxidant. This dual antioxidant emulsion system provides new opportunities for the transmission of oxidation-prone nutrients, and its prospects are optimistic.

中文翻译：

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通过在水相和油相中强化的双重天然抗氧化剂，增强富含不饱和脂肪酸的乳液的稳定性

摘要 含有不饱和脂肪酸 (UFA) 的乳剂在治疗临床营养不良方面具有潜力。然而，由于双键的存在，UFAs的稳定性是一个主要问题，容易被氧化，导致营养损失，甚至产生副作用。影响UFAs的因素复杂，单一抗氧化剂的保护作用并不理想。该研究的目标是开发具有更高稳定性的富含 UFA 的水包油 (O/W) 乳液，同时采用亲水性（儿茶酚）和疏水性（生育酚）抗氧化剂，然后研究其稳定机制用于乳剂的儿茶酚和生育酚。本研究中获得的乳液在加速条件下显示出均匀的纳米级液滴和良好的储存稳定性三个月。超过 93.0% 的脂肪酸在储存 6 个月后保持不变，这证明了儿茶酚和生育酚的保护作用。与含有单一抗氧化剂或不含任何抗氧化剂的乳液相比，双重抗氧化剂乳液在保护 UFA 方面非常有效。这种双抗氧化乳液体系为易氧化的营养物质的传输提供了新的机会，其前景十分乐观。与含有单一抗氧化剂或不含任何抗氧化剂的乳液相比，双重抗氧化剂乳液在保护 UFA 方面非常有效。这种双抗氧化乳液体系为易氧化的营养物质的传递提供了新的机会，其前景十分乐观。与含有单一抗氧化剂或不含任何抗氧化剂的乳液相比，双重抗氧化剂乳液在保护 UFA 方面非常有效。这种双抗氧化乳液体系为易氧化的营养物质的传输提供了新的机会，其前景十分乐观。