The proposed work introduces an electrochemical sensor based on an Fe₃O₄/Ag nanocomposite for highly sensitive and selective electrochemical determination of dicyclomine hydrochloride (DcCl) using adsorptive stripping square wave voltammetry (AdSSWV). A nanocomposite of silver decorated Fe₃O₄ nanocubes has been synthesized using a facile sonochemical method. The prepared nanocomposite was characterized using various characterization techniques. The impact of various parameters such as pH, scan rate, accumulation potential and accumulation time on peak current was studied employing different techniques including differential pulse voltammetry (DPV), cyclic voltammetry (CV) and AdSSWV. Under the optimized conditions, the peak current is found to be linearly proportional to the DcCl concentration in a wide linear working range from 2.0 × 10⁻⁷ to 8.0 × 10⁻⁴ M with a limit of detection (LOD) and a limit of quantification (LOQ) of 4.8 × 10⁻⁹ M and 1.6 × 10⁻⁸ M, respectively. The fabricated sensor exhibited high sensitivity and selectivity along with good stability and reproducibility, and therefore the proposed method can serve as an excellent platform for the determination of DcCl at the nanomolar level with adequate recovery in pharmaceutical as well as biological samples.

中文翻译：

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药物和生物样品中 银修饰的Fe ₃ O ₄纳米立方体修饰的玻碳电极上的吸附溶出伏安法测定盐酸二环胺†

拟议的工作介绍了一种基于Fe ₃ O ₄ / Ag纳米复合材料的电化学传感器，用于使用吸附溶出方波伏安法（AdSSWV）进行高灵敏和选择性的电化学测定盐酸二环胺（DcCl）。纳米银复合材料装饰的Fe ₃ O ₄使用简便的声化学方法已经合成了纳米立方体。使用各种表征技术对制备的纳米复合材料进行表征。使用不同的技术（包括差分脉冲伏安法（DPV），循环伏安法（CV）和AdSSWV）研究了pH，扫描速率，累积电势和累积时间等各种参数对峰值电流的影响。在最佳条件下，发现峰值电流与DcCl浓度呈线性比例关系，线性检测范围从2.0×10 ^-7到8.0×10 ^-4 M，检测限（LOD）和定量限（LOQ）为4.8×10 ^-9 M和1.6×10 ^-8M分别。所制备的传感器显示出高灵敏度和选择性以及良好的稳定性和可重复性，因此，所提出的方法可以作为测定纳摩尔水平的DcCl的极佳平台，并能在药物和生物样品中得到足够的回收率。