In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.

中文翻译：

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新型ERα突变推动了乳腺癌的发展，并为新药开发提出了挑战。

在本期《癌细胞》中，Jeselsohn等人。解剖了与乳腺癌的内分泌治疗抗性相关的几个临床上最重要的雌激素受体α突变体的功能，并证明它们表现出与疾病有关的新形态活性，可能与肿瘤的发病机理有关。