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Effects of the electrode insertion depth on the neural signal amplitude in the spinal cord
Analytical Methods ( IF 3.1 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1039/c8ay00028j
Shijie Deng 1, 2, 3, 4 , Hai Hu 1, 2, 3, 4 , Peng Wang 1, 2, 3, 4
Affiliation  

The technique used for electrode insertion navigation is of crucial importance for neural signal collection. The spinal cord mapping method tracks the placement of electrodes throughout their insertion trajectory in vivo, allowing high accuracy for electrode insertion guidance with micrometer step resolution, but is time consuming. In the present study, we used the spinal cord mapping method to collect pain signals from the rat spinal cord. We found that the amplitude of the neural signal was approximately inversely proportional to the electrode insertion depth when the electrode was more than 30 μm away from the target neurons, and was approximately proportional to the square of the electrode insertion depth when the electrode was close to the target neurons. Based on this relationship, the amplitude of the collected neural signal can be used to determine the electrode placement to reduce time consumption for electrode positioning.

中文翻译:

电极插入深度对脊髓神经信号幅度的影响

用于电极插入导航的技术对于神经信号收集至关重要。脊髓标测方法可跟踪电极在体内整个插入轨迹的位置,以微米级的步长分辨率实现电极插入引导的高精度,但是很费时间。在本研究中,我们使用脊髓映射方法从大鼠脊髓收集疼痛信号。我们发现,当电极距离目标神经元的距离大于30μm时,神经信号的振幅与电极插入深度近似成反比,而当电极与目标神经元接近时,神经信号的振幅与电极插入深度的平方成正比。目标神经元。基于此关系,收集到的神经信号的幅度可用于确定电极位置,以减少电极定位的时间消耗。
更新日期:2018-02-12
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