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DoesAkkermansia muciniphilaplay a role in type 1 diabetes?
Gut ( IF 24.5 ) Pub Date : 2018-02-10 , DOI: 10.1136/gutjnl-2017-315732
Gilles Mithieux

A field currently attracting increasing interest concerns the possible role that the intestinal microbiota might play in human health and disease. The fact that novel sequencing approaches applied to the microbiota genome are available has definitely favoured the rapid development of this field. The recent re-emergence in this area began with studies on obesity and metabolic diseases. Various associations between microbiota composition and metabolic diseases such as obesity and type 2 diabetes have been reported, in both rodents and humans, emphasising the key role of dietary habits in the composition of the bacterial population.1–3 However, experiments aimed at changing microbiota composition and transferring/exchanging the intestinal microbiota to alter the metabolism of the host have proved somewhat controversial and failed to unequivocally establish a causal role for the gut microbiota in metabolic diseases.4 Whatever the case, it is noteworthy that a specific bacterium, Akkermansia muciniphila , an abundant constituent of the gut microbiota in healthy humans, has been demonstrated to correct host metabolic disorders when given by gavage as a probiotic in obese insulin-resistant mice.2 Nowadays, interest in the role of intestinal microbiota in …

中文翻译:

Akkermansia muciniphila 在 1 型糖尿病中起作用吗?

目前引起越来越多兴趣的领域涉及肠道微生物群在人类健康和疾病中可能发挥的作用。可用于微生物组基因组的新型测序方法的出现无疑有利于该领域的快速发展。最近该领域的重新兴起始于对肥胖和代谢疾病的研究。在啮齿动物和人类中,微生物群组成与代谢疾病(如肥胖和 2 型糖尿病)之间的各种关联已被报道,这强调了饮食习惯在细菌种群组成中的关键作用。 1-3 然而,
更新日期:2018-02-10
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