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Functional Neurocircuits and Neuroimaging Biomarkers of Tobacco Use Disorder
Trends in Molecular Medicine ( IF 13.6 ) Pub Date : 2018-02-10 , DOI: 10.1016/j.molmed.2017.12.002
Matthew T. Sutherland , Elliot A. Stein

Drug abuse and addiction remain major public health issues, exemplified by the opioid epidemic currently devastating the United States. Treatment outcomes across substance use disorders remain unacceptably poor, wherein drug discovery/development for this multifaceted neuropsychiatric disorder focuses on single molecular-level targets. Rather, our opinion is that a systems-level neuroimaging perspective is crucial for identifying novel therapeutic targets, biomarkers to stratify patients, and individualized treatment strategies. Focusing on tobacco use disorder, we advocate a brain systems-level perspective linking two abuse-related facets (i.e., statelike withdrawal and traitlike addiction severity) with specific neurocircuitry (insula- and striatum-centered networks). To the extent that precise neurocircuits mediate distinct facets of abuse, treatment development must adopt not only a systems-level perspective, but also multi-intervention rather than mono-intervention practices.



中文翻译:

烟草使用障碍的功能性神经回路和神经影像生物标志物

药物滥用和成瘾仍然是主要的公共卫生问题,阿片类药物流行病目前正在席卷美国。跨物质使用障碍的治疗结果仍然令人难以接受,其中针对这种多方面的神经精神障碍的药物发现/开发集中在单个分子水平的靶标上。相反,我们的观点是,系统级的神经影像学观点对于确定新的治疗靶标,对患者进行分层的生物标志物以及个性化的治疗策略至关重要。着眼于烟草使用障碍,我们主张将两个与滥用相关的方面(即状态性戒断和特质性上瘾的严重程度)与特定的神经回路(以胰岛素和纹状体为中心的网络)联系起来的大脑系统水平的观点。在一定程度上,精确的神经回路介导了虐待的不同方面,

更新日期:2018-02-10
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