A continuous flow synthesis of tryptophol is developed in a tubular reactor at different temperatures and flow rates, by Fischer indole synthesis route using phenyl hydrazine hydrochloride (PHH) and 2,3-dihydrofuran (DHF) as starting materials. The maximum conversion of PHH was 93%, and the yield of tryptophol was 72% in 6 min. A kinetic model is proposed for the process by taking into account the formation of intermediate species. The reactor was simulated in COMSOL platform for temperature profiles in the reactor, which were subsequently used to estimate the kinetic parameters of the reaction. The reaction was further intensified by executing the reaction in a continuous microwave reactor (CMWR), at different flow rates and at different power. The maximum conversion of PHH was obtained to be 91%, and the yield of tryptophol was 95% in 5 min using CMWR.

中文翻译：

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Tryptophol连续流合成的工艺强化

通过使用苯肼盐酸盐（PHH）和2,3-二氢呋喃（DHF）作为原料的费歇尔吲哚合成路线，在管式反应器中以不同的温度和流速进行了三氯酚的连续流动合成。在6分钟内，PHH的最大转化率为93％，而三酚的产率为72％。通过考虑中间物种的形成，为该过程提出了动力学模型。在COMSOL平台中对反应器进行了仿真，以了解反应器中的温度曲线，随后将其用于估算反应的动力学参数。通过在连续的微波反应器（CMWR）中以不同的流速和功率进行反应来进一步增强反应。PHH的最大转化率为91％，