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Human DNA polymerase θ does not harbor intrinsic nuclease activity Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Denisse Carvajal-Maldonado, Karl Zahn, Ryan Jensen, Richard D. Wood, Sylvie Doublié
Abstract not available
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Meet the authors: Guy Zoltsman and Rina Rosenzweig Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Guy Zoltsman, Rina Rosenzweig
We talk to first and last authors Guy Zoltsman and Rina Rosenzweig about their paper, “A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53,” how every result may be important in the right context, and the importance to Rina that her lab is an encouraging and collaborative place.
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Entangling and disentangling mitotic chromosomes Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Jonathan Baxter
The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.1 describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.
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Free ribosomal proteins as culprits for nucleolar stress Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Ina Huppertz
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.
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Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Dylan M. Parker, Gaia R. Bublitz, Roy Parker
In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover
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Sequential requirements for distinct Polθ domains during theta-mediated end joining Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li, Dale A. Ramsden, Richard D. Wood, Sylvie Doublié, Eli Rothenberg
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No evidence for ac4C within human mRNA upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Joseph Georgeson, Schraga Schwartz
Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T suggested widespread ac4C presence. Here, we reanalyze RedaC:T data. We find that mismatch signatures are not reproducible, as C>T mismatches are nearly
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Detection of ac4C in human mRNA is preserved upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Hamid Beiki, David Sturgill, Daniel Arango, Sebastien Relier, Sarah Schiffers, Shalini Oberdoerffer
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an earlier report from Schwartz and colleagues utilizing a similar method termed ac4C-seq. Here, we revisit both datasets and reaffirm our findings. Through RedaC:T-seq reanalysis, we establish
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Retraction Notice to: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Karl E. Zahn, Ryan B. Jensen, Richard D. Wood, Sylvie Doublie
Abstract not available
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Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Nathanael A. Caveney, Grayson E. Rodriguez, Christoph Pollmann, Thomas Meyer, Marta T. Borowska, Steven C. Wilson, Nan Wang, Xinyu Xiang, Karsten D. Householder, Pingdong Tao, Leon L. Su, Robert A. Saxton, Jacob Piehler, K. Christopher Garcia
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Marius Hedtfeld, Alicia Dammers, Carolin Koerner, Andrea Musacchio
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Learning from chromatin reconstitution: Pioneer factors enabling nucleosome remodelers Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Ken Zaret
No Abstract
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yaqiang Hong, Luyao Bie, Tao Zhang, Xiaohan Yan, Guangpu Jin, Zhuo Chen, Yang Wang, Xiufeng Li, Gaofeng Pei, Yongyan Zhang, Yantao Hong, Liang Gong, Pilong Li, Wei Xie, Yanfen Zhu, Xiaohua Shen, Nian Liu
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Three-step mechanism of promoter escape by RNA polymerase II Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yumeng Zhan, Frauke Grabbe, Elisa Oberbeckmann, Christian Dienemann, Patrick Cramer
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Response to “Learning from chromatin reconstitution: Pioneering factors enabling nucleosome remodelers” Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Kami Ahmad, Sandipan Brahma, Steven Henikoff
Abstract not available
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An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains Mol. Cell (IF 16.0) Pub Date : 2024-04-09 Luigi Lerra, Martina Panatta, Dominik Bär, Isabella Zanini, Jennifer Yihong Tan, Agnese Pisano, Chiara Mungo, Célia Baroux, Vikram Govind Panse, Ana C. Marques, Raffaella Santoro
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Enhancer switching in cell lineage priming is linked to eRNA, Brg1’s AT-hook, and SWI/SNF recruitment Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, McKenzie M. Murvin, Yue Lu, J. Mauro Calabrese, Blaine Bartholomew
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BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Haoyang Jiang, Tianpeng Zhang, Hardeep Kaur, Tao Shi, Aravind Krishnan, Youngho Kwon, Patrick Sung, Roger A. Greenberg
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Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle Mol. Cell (IF 16.0) Pub Date : 2024-04-08 Yeon Choi, Buyeon Um, Yongwoo Na, Jeesoo Kim, Jong-Seo Kim, V. Narry Kim
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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability Mol. Cell (IF 16.0) Pub Date : 2024-04-02 Jin-Dong Hao, Qian-Lan Liu, Meng-Xia Liu, Xing Yang, Liu-Ming Wang, Si-Yi Su, Wen Xiao, Meng-Qi Zhang, Yi-Chang Zhang, Lan Zhang, Yu-Sheng Chen, Yun-Gui Yang, Jie Ren
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eIF4F is a thermo-sensing regulatory node in the translational heat shock response Mol. Cell (IF 16.0) Pub Date : 2024-03-27 Christine Desroches Altamirano, Moo-Koo Kang, Mareike A. Jordan, Tom Borianne, Irem Dilmen, Maren Gnädig, Alexander von Appen, Alf Honigmann, Titus M. Franzmann, Simon Alberti
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Molecular determinants and signaling effects of PKA RIα phase separation Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Julia C. Hardy, Emily H. Pool, Jessica G.H. Bruystens, Xin Zhou, Qingrong Li, Daojia R. Zhou, Max Palay, Gerald Tan, Lisa Chen, Jaclyn L.C. Choi, Ha Neul Lee, Stefan Strack, Dong Wang, Susan S. Taylor, Sohum Mehta, Jin Zhang
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The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L. Black
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Modularity of PRC1 composition and chromatin interaction define condensate properties Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Stefan Niekamp, Sharon K. Marr, Theresa A. Oei, Radhika Subramanian, Robert E. Kingston
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Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Oleksandra Sirozh, Anabel Saez-Mas, Bomi Jung, Laura Sanchez-Burgos, Eduardo Zarzuela, Sara Rodrigo-Perez, Ivan Ventoso, Vanesa Lafarga, Oscar Fernandez-Capetillo
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Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Erica M. Hildebrand, Kirill Polovnikov, Bastiaan Dekker, Yu Liu, Denis L. Lafontaine, A. Nicole Fox, Ying Li, Sergey V. Venev, Leonid A. Mirny, Job Dekker
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Prajwal C. Boddu, Abhishek K. Gupta, Rahul Roy, Bárbara De La Peña Avalos, Anne Olazabal-Herrero, Nils Neuenkirchen, Joshua T. Zimmer, Namrata S. Chandhok, Darren King, Yasuhito Nannya, Seishi Ogawa, Haifan Lin, Matthew D. Simon, Eloise Dray, Gary M. Kupfer, Amit Verma, Karla M. Neugebauer, Manoj M. Pillai
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A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Yuleika G. Martinez Castillo, Chantell S. Evans
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How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Shasha Chong, Shawn Yoshida
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Integrating the response to stressed mitochondria Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Elliot Dine, Richard J. Youle
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Meet the authors: Jayoung Ku, Keonyong Lee, and Yoosik Kim Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Jayoung Ku, Keonyong Lee, Yoosik Kim
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H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation Mol. Cell (IF 16.0) Pub Date : 2024-03-20 Naoki Kubo, Poshen B. Chen, Rong Hu, Zhen Ye, Hiroyuki Sasaki, Bing Ren
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ERMA (TMEM94) is a P-type ATPase transporter for Mg2+ uptake in the endoplasmic reticulum Mol. Cell (IF 16.0) Pub Date : 2024-03-20 Neelanjan Vishnu, Manigandan Venkatesan, Travis R. Madaris, Mridula K. Venkateswaran, Kristen Stanley, Karthik Ramachandran, Adhishree Chidambaram, Abitha K. Madesh, Wenli Yang, Jyotsna Nair, Melanie Narkunan, Tharani Muthukumar, Varsha Karanam, Leroy C. Joseph, Amy Le, Ayodeji Osidele, M. Imran Aslam, John P. Morrow, May C. Malicdan, Peter B. Stathopulos, Muniswamy Madesh
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis Mol. Cell (IF 16.0) Pub Date : 2024-03-19 Joel William Francis, Simone Hausmann, Sabeen Ikram, Kunlun Yin, Robert Mealey-Farr, Natasha Mahealani Flores, Annie Truc Trinh, Tourkian Chasan, Julia Thompson, Pawel Karol Mazur, Or Gozani
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A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53 Mol. Cell (IF 16.0) Pub Date : 2024-03-19 Guy Zoltsman, Thi Lieu Dang, Miriam Kuchersky, Ofrah Faust, Micael S. Silva, Tal Ilani, Anne S. Wentink, Bernd Bukau, Rina Rosenzweig
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1 Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Tristen Wright, Meghan E. Turnis, Christy R. Grace, Xiao Li, Lauren A. Brakefield, Yong-Dong Wang, Haiyan Xu, Ewa Kaminska, Leslie K. Climer, Tresor O. Mukiza, Chi-Lun Chang, Tudor Moldoveanu, Joseph T. Opferman
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Pinki Gahlot, Bojana Kravic, Giulia Rota, Johannes van den Boom, Sophie Levantovsky, Nina Schulze, Elena Maspero, Simona Polo, Christian Behrends, Hemmo Meyer
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A kinetic dichotomy between mitochondrial and nuclear gene expression processes Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Erik McShane, Mary Couvillion, Robert Ietswaart, Gyan Prakash, Brendan M. Smalec, Iliana Soto, Autum R. Baxter-Koenigs, Karine Choquet, L. Stirling Churchman
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Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency Mol. Cell (IF 16.0) Pub Date : 2024-03-14 David Lando, Xiaoyan Ma, Yang Cao, Aleksandra Jartseva, Tim J. Stevens, Wayne Boucher, Nicola Reynolds, Bertille Montibus, Dominic Hall, Andreas Lackner, Ramy Ragheb, Martin Leeb, Brian D. Hendrich, Ernest D. Laue
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A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice Mol. Cell (IF 16.0) Pub Date : 2024-03-12 Xiaoding Ma, Jianli Yin, Longliang Qiao, Hang Wan, Xingwan Liu, Yang Zhou, Jiali Wu, Lingxue Niu, Min Wu, Xinyi Wang, Haifeng Ye
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Imprinted X chromosome inactivation at the gamete-to-embryo transition Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Chunyao Wei, Barry Kesner, Hao Yin, Jeannie T. Lee
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H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Jicheng Zhao, Jie Lan, Min Wang, Cuifang Liu, Zheng Fang, Aoqun Song, Tiantian Zhang, Liang Wang, Bing Zhu, Ping Chen, Juan Yu, Guohong Li
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Gergely Rona, Bearach Miwatani-Minter, Qingyue Zhang, Hailey V. Goldberg, Marc A. Kerzhnerman, Jesse B. Howard, Daniele Simoneschi, Ethan Lane, John W. Hobbs, Elizabeth Sassani, Andrew A. Wang, Sarah Keegan, Daniel J. Laverty, Cortt G. Piett, Lorinc S. Pongor, Miranda Li Xu, Joshua Andrade, Anish Thomas, Piotr Sicinski, Manor Askenazi, Beatrix Ueberheide, David Fenyö, Zachary D. Nagel, Michele Pagano
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Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Kyung Lock Kim, Gilbert J. Rahme, Viraat Y. Goel, Chadi A. El Farran, Anders S. Hansen, Bradley E. Bernstein
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Alternative splicing decouples local from global PRC2 activity Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Niccolò Arecco, Ivano Mocavini, Enrique Blanco, Cecilia Ballaré, Elina Libman, Sophie Bonnal, Manuel Irimia, Luciano Di Croce
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Sister chromatid cohesion halts DNA loop expansion Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Nathalie Bastié, Christophe Chapard, Axel Cournac, Sanae Nejmi, Henri Mboumba, Olivier Gadal, Agnès Thierry, Frederic Beckouët, Romain Koszul
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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease Mol. Cell (IF 16.0) Pub Date : 2024-03-05 Kwamina Nyame, Andy Hims, Aya Aburous, Nouf N. Laqtom, Wentao Dong, Uche N. Medoh, Julia C. Heiby, Jian Xiong, Alessandro Ori, Monther Abu-Remaileh
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Structural atlas of human primary microRNAs generated by SHAPE-MaP Mol. Cell (IF 16.0) Pub Date : 2024-03-05 S. Chan Baek, Boseon Kim, Harim Jang, Kijun Kim, Il-Soo Park, Dal-Hee Min, V. Narry Kim
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Structure of the multi-subunit chloroplast RNA polymerase Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Paula F.V. do Prado, Frederik M. Ahrens, Monique Liebers, Noah Ditz, Hans-Peter Braun, Thomas Pfannschmidt, Hauke S. Hillen
Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by a plastid-encoded RNA polymerase (PEP), a nearly 1 MDa complex composed of core subunits with homology to eubacterial RNA polymerases (RNAPs) and at least 12 additional chloroplast-specific PEP-associated proteins (PAPs). However, the architecture
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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Gayathri Muthukumar, Taylor A. Stevens, Alison J. Inglis, Theodore K. Esantsi, Reuben A. Saunders, Fabian Schulte, Rebecca M. Voorhees, Alina Guna, Jonathan S. Weissman
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis Mol. Cell (IF 16.0) Pub Date : 2024-02-28 Kaiwen Bao, Yanhui Ma, Yuan Li, Xilin Shen, Jiao Zhao, Shanshan Tian, Chunyong Zhang, Can Liang, Ziyan Zhao, Ying Yang, Kai Zhang, Na Yang, Fei-long Meng, Jihui Hao, Jie Yang, Tao Liu, Zhi Yao, Ding Ai, Lei Shi
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The proteomic landscape of genotoxic stress-induced micronuclei Mol. Cell (IF 16.0) Pub Date : 2024-02-28 Kate M. MacDonald, Shahbaz Khan, Brian Lin, Rose Hurren, Aaron D. Schimmer, Thomas Kislinger, Shane M. Harding
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Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Bonnie G. Su, Seychelle M. Vos
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Hao Li, Zhejian Ji, Joao A. Paulo, Steven P. Gygi, Tom A. Rapoport
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Discovery of cytosine deaminases enables base-resolution methylome mapping using a single enzyme Mol. Cell (IF 16.0) Pub Date : 2024-02-22 Romualdas Vaisvila, Sean R. Johnson, Bo Yan, Nan Dai, Billal M. Bourkia, Minyong Chen, Ivan R. Corrêa, Erbay Yigit, Zhiyi Sun
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Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Hafez El Sayyed, Oliver J. Pambos, Mathew Stracy, Max E. Gottesman, Achillefs N. Kapanidis
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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Jimmy K. Guo, Mario R. Blanco, Ward G. Walkup IV, Grant Bonesteele, Carl R. Urbinati, Abhik K. Banerjee, Amy Chow, Olivia Ettlin, Mackenzie Strehle, Parham Peyda, Enrique Amaya, Vickie Trinh, Mitchell Guttman
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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting Mol. Cell (IF 16.0) Pub Date : 2024-02-20 Jerry Li, Nicholas Purser, Joanna Liwocha, Daniel C. Scott, Holly A. Byers, Barbara Steigenberger, Spencer Hill, Ishita Tripathi-Giesgen, Trent Hinkle, Fynn M. Hansen, J. Rajan Prabu, Senthil K. Radhakrishnan, Donald S. Kirkpatrick, Kurt M. Reichermeier, Brenda A. Schulman, Gary Kleiger
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Chuan He, Xixin Xing, Hsin-Yi Chen, Minling Gao, Jie Shi, Bolin Xiang, Xiangling Xiao, Yishuang Sun, Haisheng Yu, Gaoshan Xu, Yingmeng Yao, Zuosong Xie, Yujie Xing, Bugi Ratno Budiarto, Shih-Yu Chen, Yang Gao, Yu-Ru Lee, Jinfang Zhang