In this study, nondegradable poly (carbonate urethane) (PCU) and poly (carbonate urethane) incorporated variable Fe₃O₄ content microspheres (PCU/Fe₃O₄) were synthesized using pre-polymerization and suspension polymerization. Synthesis was confirmed through Fourier transform infrared spectroscopy (FTIR). The effect of Fe₃O₄ incorporation was investigated on crystalline, thermal, shape memory and degradation properties by X-Ray diffraction (XRD), Differential scanning calorimetery (DSC), compression test and degradation in vitro, respectively. Otherwise, the assessment of magnetic characteristics by vibrational sample magnetometry (VSM) disclosed superparamagnetic behavior. The tunable superparamagnetic behavior depends on the amount of magnetic particles incorporated within the networks. The biological study results of as-synthesized polymers from the platelet adhesion test and the cell proliferation inhibition test indicated they were biocompatible in vitro. Fe₃O₄ incorporation was conductive to reducing platelet adhesion in blood contacting test and promotion of rat vascular smooth muscle cell proliferation and growth. These nondegradable, superparamagnetic, biocompatible polymers, combined with their good shape memory properties may allow for their future exploitation in the biomedical field, such as, in cardiovascular implants, targeted tumor treatment, tissue engineering and artificial organ's engineering.

在这项研究中，使用预聚合和悬浮聚合合成了不可降解的聚碳酸亚乙酯（PCU）和掺入了可变的Fe ₃ O ₄含量的微球（PCU / Fe ₃ O ₄）。通过傅里叶变换红外光谱法（FTIR）证实了合成。Fe ₃ O _4的作用分别通过X射线衍射（XRD），差示扫描量热法（DSC），压缩测试和体外降解研究了掺入的晶体，热，形状记忆和降解特性。否则，通过振动样品磁强计（VSM）进行的磁特性评估显示了超顺磁行为。可调节的超顺磁性行为取决于网络中结合的磁性粒子的数量。来自血小板粘附试验和细胞增殖抑制试验的合成聚合物的生物学研究结果表明，它们在体外具有生物相容性。铁₃ O ₄掺入有助于减少血液接触试验中的血小板粘附并促进大鼠血管平滑肌细胞的增殖和生长。这些不可降解的，超顺磁性的生物相容性聚合物，再加上其良好的形状记忆性能，可使其在生物医学领域中得到进一步利用，例如在心血管植入物，靶向肿瘤治疗，组织工程和人工器官工程中。