The morphology of plasma membrane is dynamic and keeps changing in order to maintain its homeostasis. Abnormality in cell membrane shape could be viewed as a sign of unhealthy cells. A lipophilic cyanostilbene derivative (AS2CP-TPA) composed of a hydrophilic pyridinium salt and a hydrophobic triphenylamino group was designed for staining the cell membrane and monitoring membrane morphology under different conditions. Due to strong donor–acceptor interaction and aggregation-induced emission property, AS2CP-TPA emits weak emission in aqueous solution, but it lights up the plasma membrance of HeLa cells with near infrared fluorescence under an excitation wavelength of 460 nm. With merits of high photostability and high specificity to plasma membrane, AS2CP-TPA is capable of long-term monitoring of the morphological changes of cell membrane during Hg²⁺ and trypsin treatments.

中文翻译：

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具有光稳定性的AIE发光剂，具有近红外发射，可监测质膜的形态变化†

质膜的形态是动态的，并不断变化以维持其稳态。细胞膜形状异常可被视为不健康细胞的迹象。设计了由亲水性吡啶鎓盐和疏水性三苯氨基组成的亲脂性氰基苯乙烯衍生物（AS2CP-TPA），用于在不同条件下染色细胞膜并监测膜的形态。由于强的供体-受体相互作用和聚集诱导的发射特性，AS2CP-TPA在水溶液中发射的发射微弱，但在460 nm的激发波长下，它以近红外荧光点亮了HeLa细胞的质膜。AS2CP-TPA具有高光稳定性和对质膜高特异性的优点，能够长期监测汞中细胞膜的形态变化²⁺和胰蛋白酶治疗。