As a synthetic methodology, C–H activation represents a complimentary protocol to traditional cross-couplings such as the Suzuki–Miyaura and Stille reactions, by avoiding the extra synthetic steps required to install activating groups. C–H activation also often avoids the production of waste associated with B, Sn, halide etc. Pd-catalysed transformations have been most prominent in the C–H activation realm. However, as a society we are over-reliant on transitional metals, cost is increasing, and the accessible supply is dwindling. One potential solution is to develop chemistry using Earth Abundant Metals (EAMs). Manganese (Mn), in particular, demonstrates great promise. Since the publication of an excellent review by Ackermann in 2016 (ACS Catal. 2016, 6, 3743–3652), there has been a flurry of reports on Mn-catalysed C–H activation. We report here an overview of approximately 30 new papers, which include a number of notable advances since April 2016.

中文翻译：

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锰催化的CH活化的最新进展：范围和机理

作为一种合成方法，CH活化代表了传统交叉偶联（如Suzuki-Miyaura和Stille反应）的补充方案，它避免了安装活化基团所需的额外合成步骤。C–H活化通常还避免产生与B，Sn，卤化物等有关的废物。Pd催化的转化在C–H活化领域中最为突出。但是，作为一个社会，我们过度依赖过渡金属，成本在增加，可获取的供应却在减少。一种潜在的解决方案是使用地球多种金属（EAM）开发化学方法。尤其是锰（Mn）具有广阔的前景。由于优异的审查的在2016年（在出版物通过阿克曼ACS CATAL。 2016年，6（3743–3652），关于锰催化的C–H活化的报道很多。我们在这里报告了大约30篇新论文的概述，其中包括自2016年4月以来的许多显着进展。