Background

There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources.

Objectives

This study sought to investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases.

Methods

In a population-based birth cohort, we measured IgE to 112 components at 6 follow-ups during childhood. We used a Bayesian method to discover cross-sectional sensitization patterns and their longitudinal trajectories, and we related these patterns to asthma and rhinitis in adolescence.

Results

We identified 1 sensitization cluster at age 1, 3 at age 3, 4 at ages 5 and 8, 5 at age 11, and 6 at age 16 years. “Broad” cluster was the only cluster present at every follow-up, comprising components from multiple sources. “Dust mite” cluster formed at age 3 years and remained unchanged to adolescence. At age 3 years, a single-component “Grass” cluster emerged, which at age 5 years absorbed additional grass components and Fel d 1 to form the “Grass/cat” cluster. Two new clusters formed at age 11 years: “Cat” cluster and “PR-10/profilin” (which divided at age 16 years into “PR-10” and “Profilin”). The strongest contemporaneous associate of asthma at age 16 years was sensitization to dust mite cluster (odds ratio: 2.6; 95% CI: 1.2-6.1; P < .05), but the strongest early life predictor of subsequent asthma was sensitization to grass/cat cluster (odds ratio: 3.5; 95% CI: 1.6-7.4; P < .01).

Conclusions

We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases.

中文翻译：

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整个儿童期对多种过敏原成分的IgE反应的演变

背景

关于来自多种来源的对变应原性蛋白质（组分）的IgE反应的纵向模式的信息很少。

目标

这项研究试图调查从婴儿期到青春期的特定组分IgE反应的时间模式，以及它们与过敏性疾病的关系。

方法

在以人群为基础的出生队列中，我们在儿童期的6次随访中测量了112种成分的IgE。我们使用贝叶斯方法来发现横断面敏化模式及其纵向轨迹，并将这些模式与青春期的哮喘和鼻炎相关联。

结果

我们在1岁时确定了1个致敏簇，在3岁时出现了3个，在5和8岁时出现了4个，在11岁时出现了5个，在16岁时出现了6个。“广泛”集群是每次随访中存在的唯一集群，包括来自多个来源的组件。“尘螨”团簇在3岁时形成，并一直保持到青春期。在3岁时，出现了一个单一成分的“草”群，在5岁时，它吸收了其他草成分和Fel d 1，形成了“草/猫”群。在11岁时形成了两个新的类别：“猫”类别和“ PR-10 / profilin”（在16岁时分为“ PR-10”和“ Profilin”）。16岁时哮喘最强的同期伴发者是对尘螨集群的敏感性（赔率：2.6； 95％CI：1.2-6.1；P <0.05），但随后哮喘最强的早期生命预测指标是对草/猫群的敏感度（几率​​：3.5； 95％CI：1.6-7.4；P  <.01）。

结论

我们描述了整个儿童期对多种过敏原成分的IgE反应进化的体系结构，这可能会促进过敏性疾病更好的诊断和预后生物标记物的开发。