Bimetal catalysts are good alternatives for non-enzymatic glucose sensors owing to their low cost, high activity, good conductivity, and ease of fabrication. In the present study, a self-supported CuNi/C electrode prepared by electrodepositing Cu nanoparticles on a Ni-based metal–organic framework (MOF) derivate was used as a non-enzymatic glucose sensor. The porous construction and carbon scaffold inherited from the Ni-MOF guarantee good kinetics of the electrode process in electrochemical glucose detection. Furthermore, Cu nanoparticles disturb the array structure of MOF derived films and evidently enhance their electrochemical performances in glucose detection. Electrochemical measurements indicate that the CuNi/C electrode possesses a high sensitivity of 17.12 mA mM⁻¹ cm⁻², a low detection limit of 66.67 nM, and a wider linearity range from 0.20 to 2.72 mM. Additionally, the electrode exhibits good reusability, reproducibility, and stability, thereby catering to the practical use of glucose sensors. Similar values of glucose concentrations in human blood serum samples are detected with our electrode and with the method involving glucose-6-phosphate dehydrogenase; the results further demonstrate the practical feasibility of our electrode.

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双金属催化剂因其低成本，高活性，良好的导电性和易于制造而成为非酶葡萄糖传感器的良好替代品。在本研究中，通过将铜纳米颗粒电沉积在基于镍的金属-有机骨架（MOF）衍生物上制备的自支撑CuNi / C电极用作非酶葡萄糖传感器。Ni-MOF继承的多孔结构和碳支架确保了电化学葡萄糖检测中电极过程的良好动力学。此外，铜纳米粒子扰乱了MOF衍生膜的阵列结构，并明显增强了其在葡萄糖检测中的电化学性能。电化学测量表明，CuNi / C电极具有17.12 mA mM ^-1  cm ^-2的高灵敏度，检测限低至66.67 nM，线性范围较宽，介于0.20至2.72 mM之间。另外，该电极表现出良好的可重复使用性，可再现性和稳定性，从而适应葡萄糖传感器的实际使用。用我们的电极和涉及葡萄糖-6-磷酸脱氢酶的方法可以检测到人血清样品中葡萄糖浓度的相似值。结果进一步证明了我们电极的实际可行性。

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