The Front Cover shows a blueprint of a defined carbohydrate (candy) that is literally devoured by the bacterial cell via maltodextrin transporters. Attaching an imaging label to this carbohydrate allows it to be tracked (yellow shine) and potentially allows sensitive detection and localization of bacterial infection in vivo. The study has identified essential structural features of the tracer molecule to make it less vulnerable to enzymatic degradation (green icons) in the blood. This approach facilitates intracellular accumulation via maltodextrin transporters thereby lightening up the bacterial cell and colony, respectively. More information can be found in the Full Paper by Ryan Gilmour, Andreas Faust et al. on page 241 in Issue 3, 2018 (DOI: 10.1002/cmdc.201700543).

中文翻译：

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封面：利用麦芽糖糊精转运机制进行靶向细菌成像：示踪剂设计中改善体内稳定性的结构要求（ChemMedChem 3/2018）

封面显示了一种确定的碳水化合物（糖果）的蓝图，该碳水化合物实际上是由麦芽糖糊精转运蛋白吞噬了细菌细胞的。将成像标签附着到这种碳水化合物上可以对其进行跟踪（发黄光），并可能允许对体内细菌感染进行灵敏的检测和定位。这项研究确定了示踪剂分子的基本结构特征，以使其不易受到血液中酶促降解的影响（绿色图标）。该方法通过麦芽糖糊精转运蛋白促进细胞内积累，从而分别减轻细菌细胞和菌落。有关更多信息，请参见Andreas Faust等人的Ryan Gilmour的论文全文。关于在第3期，2018第241页（：10.1002 / cmdc.201700543 DOI）。