A simple, facile, selective and cost effective electrochemical method is proposed for the determination of telmisartan (TMS); a drug used for hypertension. A sodium dodecyl sulfate (SDS) modified edge plane pyrolytic graphite (EPPG) is prepared by simple immersion of EPPG in SDS solution at concentration greater than critical micelle concentration (CMC). The modified sensor exhibited superior sensing properties towards the oxidation of TMS. The modified surface was characterized by using the Energy dispersive X‐ray analysis, Field Emission Scanning Electron Microscopy, Electrochemical Impedance Spectroscopy and cyclic voltammetry. The quantitative investigations of the TMS were performed by applying the square wave voltammetry. The micelles of SDS form a pseudo complex with cation radical of TMS and catalyse the oxidation. The proposed sensor shows the linear calibration plot in the concentration range of 5–100 μM with sensitivity 0.2983 μA/μM and the limit of the detection of the sensor was found to be 0.082 μM. The specificity of the developed sensor was also evaluated in the presence of commonly present interfering substances in biological samples. The amount of TMS excreted in urine of the patients undergoing treatment has also been determined. The proposed method can be effectively applied for the investigation of TMS in pharmaceutical formulations and biological samples.

中文翻译：

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十二烷基硫酸钠修饰的热解石墨表面的替米沙坦的简便，高效测定

提出了一种简单，简便，选择性和成本有效的电化学方法来测定替米沙坦（TMS）。一种用于高血压的药物。通过将EPPG简单地浸入浓度大于临界胶束浓度（CMC）的SDS溶液中，即可制备十二烷基硫酸钠（SDS）改性的边缘平面热解石墨（EPPG）。改进的传感器对TMS的氧化表现出优异的感测性能。通过使用能量色散X射线分析，场发射扫描电子显微镜，电化学阻抗谱和循环伏安法对改性后的表面进行表征。通过应用方波伏安法对TMS进行定量研究。SDS的胶束与TMS的阳离子自由基形成假络合物并催化氧化。建议的传感器在5-100μM的浓度范围内显示线性校准图，灵敏度为0.2983μA/μM，发现传感器的检出限为0.082μM。在生物样品中存在常见干扰物质的情况下，还评估了开发的传感器的特异性。还确定了接受治疗的患者尿液中TMS的排泄量。所提出的方法可以有效地应用于药物制剂和生物样品中TMS的研究。在生物样品中存在常见干扰物质的情况下，还评估了开发的传感器的特异性。还确定了接受治疗的患者尿液中TMS的排泄量。所提出的方法可以有效地应用于药物制剂和生物样品中TMS的研究。在生物样品中存在常见干扰物质的情况下，还评估了开发的传感器的特异性。还确定了接受治疗的患者尿液中TMS的排泄量。所提出的方法可以有效地应用于药物制剂和生物样品中TMS的研究。