Sealed with a twist: The incorporation of a short α‐helix into a macrocyclic scaffold resulted in a full α‐helix that is stable even at the helical ends. The designed peptide, like a miniprotein, showed high thermodynamic stability and a cooperative folding transition.

中文翻译：

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嵌入大环中的短热稳定α-螺旋的设计

用扭曲密封：将短的α螺旋掺入大环骨架中，形成完整的α螺旋，即使在螺旋末端也稳定。所设计的肽（如小蛋白）显示出高热力学稳定性和协同折叠过渡。