BACKGROUND Obesity and metabolic abnormalities are important risk factors for knee osteoarthritis (KOA). Recent epidemiologic studies have found that a high glycemic index (GI) and glycemic load (GL) diet are associated with a higher risk for metabolic complications and cardiovascular mortality. OBJECTIVE We aimed to examine the association between dietary GI, dietary GL, and KOA among Korean adults. DESIGN This was a cross-sectional study that analyzed data obtained from the Korean National Health and Nutrition Examination Survey 2010-2012. PARTICIPANTS/SETTING A total of 9,203 participants (5,275 women) aged ≥50 years were included. MAIN OUTCOME MEASURES KOA was defined as the presence of radiographic features of Kellgren-Lawrence grade ≥2. Chronic knee pain was defined as the presence of knee pain for more than 30 days during the past 3 months. Dietary information was collected using a single 24-hour recall method. STATISTICAL ANALYSES PERFORMED The association between the quintiles of dietary GI and dietary GL and knee conditions was analyzed using a multinomial logistic regression analysis adjusting for age, physical activity, obesity, hypertension and diabetes, serum low-density lipoprotein, and total energy intake. RESULTS Among the women, the association between dietary GI and symptomatic KOA was: quintile 1: 1.00 (reference); quintile 2: 1.29 (95% CI 0.87 to 1.92); quintile 3: 1.59 (95% CI 1.11 to 2.28); quintile 4: 1.74 (95% CI 1.21 to 2.51); and quintile 5: 1.77 (95% CI 1.20 to 2.60) (P=0.001). Chronic knee pain without KOA was associated with dietary GI; however, this association was not linear across quintiles. There was no significant association between dietary GI and asymptomatic KOA. Among the men, no significant association was found between dietary GI and any knee conditions. There was no significant association between dietary GL and KOA in both men and women. CONCLUSIONS There was a significant positive association between dietary GI and symptomatic KOA in women.

中文翻译：

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膳食血糖指数与膝骨关节炎之间的关联：韩国国家健康和营养检查调查 2010-2012

背景肥胖和代谢异常是膝骨关节炎（KOA）的重要危险因素。最近的流行病学研究发现，高血糖指数 (GI) 和血糖负荷 (GL) 饮食与更高的代谢并发症和心血管死亡率风险相关。目标我们旨在检查韩国成年人饮食 GI、饮食 GL 和 KOA 之间的关联。设计 这是一项横断面研究，分析了从 2010-2012 年韩国国家健康和营养检查调查中获得的数据。参与者/设置 总共包括 9,203 名年龄≥50 岁的参与者（5,275 名女性）。主要结局指标 KOA 被定义为存在凯尔格伦-劳伦斯 ≥ 2 级的放射学特征。慢性膝痛定义为在过去 3 个月内膝痛超过 30 天。饮食信息是使用单一的 24 小时回忆方法收集的。进行的统计分析 饮食 GI 的五分位数与饮食 GL 和膝关节状况之间的关联使用多项逻辑回归分析进行分析，调整了年龄、体力活动、肥胖、高血压和糖尿病、血清低密度脂蛋白和总能量摄入。结果 在女性中，饮食 GI 与症状性 KOA 之间的关联为：五分位数 1：1.00（参考）；五分位数 2：1.29（95% CI 0.87 至 1.92）；五分位数 3：1.59（95% CI 1.11 至 2.28）；五分位数 4：1.74（95% CI 1.21 至 2.51）；五分位数 5：1.77（95% CI 1.20 至 2.60）（P=0.001）。没有 KOA 的慢性膝关节疼痛与饮食 GI 相关；然而，这种关联在五分位数之间并不是线性的。饮食 GI 与无症状 KOA 之间没有显着关联。在男性中，饮食 GI 与任何膝关节状况之间未发现显着关联。男性和女性的膳食 GL 和 KOA 之间没有显着关联。结论 饮食 GI 与女性症状性 KOA 之间存在显着的正相关。