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Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2018-02-01 , DOI: 10.1016/j.tins.2017.11.007
David A. Prober

Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al. [1] (Proc. Natl. Acad. Sci. U. S. A. 1998; 95:322-327) and Sakurai et al. [2] (Cell 1998; 92: 573-585) reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that regulate sleep.

中文翻译:

Hypocretin/Orexin 的发现开创了睡眠研究的新时代

在 21 世纪之前,调节睡眠的遗传机制在很大程度上是未知的。1998 年,de Lecea 等人。[1](Proc. Natl. Acad. Sci. USA 1998; 95:322-327)和 Sakurai 等人。[2] (Cell 1998; 92: 573-585) 报道了他们分别命名为hypocretin 和orexin 的基因的发现,这导致我们对调节睡眠的遗传和神经元机制的理解发生了革命。
更新日期:2018-02-01
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