Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

中文翻译：

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MeCP2 作为基因表达的激活剂

Rett 综合征是一种主要影响女性的神经发育障碍，由甲基 CpG 结合蛋白 2 (MECP2) 基因突变引起。最初，MeCP2 已被证明是基因转录的阻遏物。在他们 2008 年的论文中，Chahrour 及其同事（DOI：10.1126/science.11​​53252）报告称，MeCP2 也可以作为转录激活剂。