In recent years, artificial materials with double helix structure have attracted widespread attention due to their unique properties such as the DNA like double-helicity, intrinsic chirality and diverse functional groups. Developing novel chiral stationary phases (CSPs) for capillary electrochromatography enantioseparation is of intriguing interest. Herein, a novel homochiral zeolite-like metal-organic framework (ZMOF) JLU-Liu23 with unique DNA like double-helicity structure was firstly utilized as the CSP in open tubular capillary electrochromatography (OT-CEC) for enantioseparation of chiral monoamine neurotransmitters and analogues. Owing to the unique DNA like double-helicity structure of the homochiral ZMOF JLU-Liu23, the good enantioseparation of four monoamine neurotransmitters and analogues was achieved on the prepared homochiral ZMOF JLU-Liu23 coated capillary column. The relative standard deviations (RSDs) of the analytes migration time for intra-day, inter-day and column-to-column were in the range of 0.3–0.6%, 0.8–2.2% and 3.5–6.5%, respectively.

近年来，具有双螺旋结构的人工材料因其独特的特性（如双螺旋，内在手性和各种官能团等DNA）而受到了广泛的关注。开发用于毛细管电色谱对映体分离的新型手性固定相（CSP）引起了人们的兴趣。本文中，首先将具有独特的双螺旋结构DNA的新型同手性沸石样金属有机骨架（ZMOF）JLU-Liu23用作开放式毛细管电色谱（OT-CEC）中的CSP，用于手性单胺神经递质和类似物的对映体分离。 。由于同质手性ZMOF JLU-Liu23具有独特的类似双螺旋结构的DNA，在制备的同手性ZMOF JLU-Liu23涂层毛细管柱上实现了四种单胺神经递质和类似物的良好对映体分离。日内，日间和柱至柱的分析物迁移时间的相对标准偏差（RSD）分别在0.3-0.6％，0.8-2.2％和3.5-6.5％的范围内。