Antihistamines such as pheniramine (PHN) or chlorpheniramine (CPH) are commonly associated with naphazoline (NPZ) in eye drops and nasal decongestants. In this work, a batch‐injection analysis system with multiple pulse amperometric (BIA‐MPA) detection has been applied for the first time for fast simultaneous determination of naphazoline (NPZ) and pheniramine (PHN) or NPZ and chlorpheniramine (CPH). PHN or CPH was selectively detected at +1.1 V and both PHN and NPZ or CPH and NPZ were detected at +1.3 V using boron doped diamond (BDD) as working electrode and Britton‐Robinson (BR) buffer (pH=10.0) as supporting electrolyte. The current of NPZ can then be obtained by subtraction of the currents detected at both potential pulses and applying a correction factor (CF). The proposed method presented good intra‐day repeatability (RSD between 0.7 and 3.2 % for PHN; 0.7 and 2.1 % for CPH; 1.5 and 4.0 % for NPZ; n=20), high analytical frequency (>80 injections h⁻¹), and limits of detection of 0.64, 0.47 and 0.11 μmol L⁻¹ for PHN, CPH and NPZ, respectively. The results obtained with the proposed method are in agreement with those obtained by HPLC (95 % confidence level).

中文翻译：

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阴极预处理硼掺杂金刚石电极测定与萘甲唑啉联用的两种抗组胺药的新型多功能方法的开发

抗组胺药如苯乙胺（PHN）或氯苯那敏（CPH）通常与滴眼液和鼻充血药中的萘甲唑啉（NPZ）相关。在这项工作中，首次使用具有多脉冲安培（BIA-MPA）检测的批注射分析系统来快速同时测定萘甲唑啉（NPZ）和苯乙胺（PHN）或NPZ和氯苯那敏（CPH）。使用硼掺杂金刚石（BDD）作为工作电极并使用Britton-Robinson（BR）缓冲液（pH = 10.0）作为支持物，在+1.1 V时选择性检测到PHN或CPH，并在+1.3 V时检测到PHN和NPZ或CPH和NPZ电解质。然后，可以通过将两个电位脉冲处检测到的电流相减并应用校正因子（CF）。所提出的方法具有良好的日内重复性（PHN的RSD在0.7到3.2％之间； CPH的0.7到2.1％； NPZ的1.5到4.0％； n = 20），高分析频率（> 80次进样h ^-1），PHN，CPH和NPZ的检出限分别为0.64、0.47和0.11μmolL ^-1。用建议的方法获得的结果与通过HPLC获得的结果（95％置信水平）相符。